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Question
Carbonic anhydrase has two substrates, carbon dioxide and bicarbonate, which are both converted to carbonic acid. Kinetic data for each is given below. Typical values for Kcat/Kmrange from less than 1 mM-1sec-1to as high as 2.8x105 mM-1sec-1. What can be said about the Kcat/Kmfor CO2?
a. carbonic anhydrase binds CO2 well but poorly converts it to carbonic acid
b. carbonic anhydrase binds CO2 poorly but effectively converts it to carbonic acid
c. carbonic anhydrase binds CO2 well and converts it to carbonic acid very well
d. carbonic anhydrase binds CO2 poorly and poorly converts it to carbonic acid
e. the data above is useless for this question
Answer
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